I was cruising along with Ronnie and ED, not long after I fixed him, and we came upon some Big Horners. I just give them a bit of room and they are no problem. I know they are enemies, red, but they never attack me. ED, I think fires on them. They ignore Ronnie and me and just tear ED to pieces. There was nothing we could do and they just stared at us in a menacing way and we left.
I often will reload last save to get a companion back but this was so unexpected and somehow fitting that I just carried on.