There was an issue for some folks where the game would try to ascertain what DLC's you had or try to install a DLC, and not having a DLC to work with, the save could get corrupted.
This did not effect everyone, and I have not seen it on the patched version I have tested.
I will close this as we have a patch thread for discussion of the patch.
http://www.gamesas.com/index.php?/topic/1149011-new-patch-12-released/