The 4GB loader shouldn't affect performance regardless (unless it does more than set the large address aware flag). The entire purpose of it is to let New Vegas use up to 4 GB of RAM, instead of only up to 2 GB of RAM. In the case of memory-bloating mods, like high resolution textures, the 4GB enabler prevents New Vegas from crashing if it uses more than 2 GB of RAM (though it'd still crash if it got up to 4 GB).
Also, somewhere it was stated that you don't need to wait for an update, it should always work.
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