The series has been parodied in The Simpsons: Virtual Springfield, which features a minigame in which Apu fights off squishee-throwing bullies in his shop with a broom, shotgun, and a weapon similar to the BFG, causing them to explode in a bloody mess, and Muppets Inside, which features a minigame in which the Swedish Chef takes on giant killer vegetables with various kitchenware. The Doomguy appears as a playable character in the PC release of Tony Hawk's Pro Skater 3. Doom is shown to be played in the film Congo, episodes of Friends and ER, and a commercial for Mystery Science Theatre 3000. The game was also referenced in the film Wild Hogs.

The game is shown briefly during an episode of Family Guy, where Stewie Griffin drives his Big Wheel through various pop culture references, which includes going through the fifth level of Doom running over an Imp. An episode[which?] of The Simpsons shows a career consultant playing Doom at his desk.

The sound effects are heard in a number of songs. "Where Boys Fear to Tread" from the album Mellon Collie and the Infinite Sadness by The Smashing Pumpkins features a rocket launcher to point to the relationship between Doom and The Smashing Pumpkins in the SPISPOPD joke. Rotten Sound's album Murderworks has a song called "Doom", in which one of the beginnings it is possible to hear some Doom sound effects, like monsters yelling and weapons firing. MF Doom, under alias Metal Fingers, sampled sound effects from Doom 64 gameplay on the song "Styrax Gum" off the album Special Herbs, Vol. 4. The song ends with the player's death. Wollt Ihr Das Bett In Flamen Sehen by Rammstein uses the player death sound from the original series several times.

Doom is often noted for its connection to satanic and unholy symbolism: the imagery, hard sound themes, and game plot. For example, when exiting the shareware version of the game, you will see a screen with more info about what is in the full registered version. Here's what a section of it says:

"... Sure, don't order DOOM. Sit back with your milk and cookies and let the universe go to Hell. Don't face the onslaught of demons and spectres that await you on The Shores of Hell. Avoid the terrifying confrontations with cacodemons and lost souls that infest Inferno. Or, act like a man! Slap a few shells into your shotgun and let's kick some demonic butt. Order the entire DOOM trilogy now! After all, youll probably end up in Hell eventually. Shouldn't you know your way around before you make the extended visit? ..."
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Another claim about the popularity and pervasiveness of Doom/Doom2 is that production in US businesses fell off substantially due to the game being played over office LANS. This could be an urban legend or a publicist's dream, but I like to think it's true. :laugh: