I noticed I really like going from level 1 to about 25-30 , after that its just, every single piece of gear/weapon you find is useless to you, and probably you have 10k+ money, starting of the game exploring is more rewarding, and leveling goes faster, but you have less perks in total... Now this may be me but who else loses abit of the "feeling" after level 30?
I find most of the challenge/fun is at lower levels: getting money, better than basic equipment, hardly any perks, stuff actually threatens you, journeys can be dangerous; that sort of thing.
I started out the game with exploring, did a few quests, visited cities - I'm level 40 now, and when exploring 'bores' me, I do some quests instead.. by the time the quests (maybe 2 or 3) are done, I go back to exploring. Never grow tired of variation