after you cure yourself of vampirism i strongly suggest you become a werewolf which will prevent you from contracting any other disease including vampirism and has no negative effects unless you actually use beast form and you can cure yourself of it any time. (once cured of it can never be werewolf again and lose disease immunity)
there IS a downside to lycanthropy....
no rest bonus.
Sleep in your own bed and you get 10% XP bonus for 8 hours
Sleep in bed with your wife and it's 15%
VERY useful when power leveling your crafting skills. Combine with "The Lovers Stone" bonus for +30% XP on all your crafting.
Cure disease potions aren't that rare, can be created, and worst case scenario you can always hit a shrine to clear diseases between quests.
Lycanthropy is only worthwhile if you actually use the ability a fair bit... BUT... your follower might attack you O.o restricting your available followers to the Companions.
It can be a fun playstyle and character ability... but it DOES have it's downsides.
Personally I cured it when given the chance.... though I've rolled up an alt Orcish warrior that will probably keep it if I ever get him that far

I've got 3 mains I'm working on already.... my dedicated werewolf and Vampire characters are both sitting below level 10 right now not getting any playtime