I'm getting a quick skip in sound when an NPC is talking, and I turn around so they are behind me, or when I'm running by and they start talking. Any ideas what this is from? I just have 2.1 speakers, and it's set that way.

Don't know the cause but for me it had something to do with leaving my PC on for a a period longer than 24 hours. Was able to fix by doing a restart

Updating your sound drivers will fix this problem.