For "the house of horrors": enter the house, go downstairs with that guy who tells you about the house, kill him (don't worry, he will attack you), talk with the daedra god and then go and find the priest (I found him in a cave, he was held prisoner). The reward is a nice mace that can absorb souls. For "the only cure": i don't remember how i got the quest but when i arrived at the shrine i didn't have a problem talking to Kesh...