For some reason, in full screen when I'm in the middle of combat or doing anything, my screen just randomly minimizes. It's like when I'm working with a normal window and it drags down. Is there any way to lock the window? (I'm using windows 7)

You've probably got something else running that redirecting the window focus.

Do you have any AV software or other stuff that runs periodically in the background at all? That's what it sounds like is going on.

The only thing I have running is FRAPS.

EDIT: This has never happened before. I don't have any new mods or 3rd party programs. The only new thing is the update. I'm not sure if that's it or not.

I have this same issue , middle of combat it drops to the desktop (minimizes) i think i figured it out though not how to fix it .
when fighting , you're swinging that mouse around and the "fullscreen" blank window Beth uses in the background doesn't reach full screen rez , so if the pointer goes to the full edge , it clicks desktop.

if you alt tab , and try to alt tab back in , it's that blank window that makes you alt tab a second time to get back into the game .

no idea how to fix this , but i can confirm this is at least MY issue, and it's repeatable.

screen rez is at 1680x1050 and set to full screen .

This has ONLY started happening since the latest update and it's a steam copy.

Yes, exactly! I wonder if it's only the steam version.

Uh, all copies use Steam. It won't make a difference.

I found something that will help. Thanks to this thread.

http://www.gamesas.com/topic/1355987-2-mouse-cursors-appearing-skyrim-windows-cursor/