Whenever I play skyrim and move the mouse, the response in game is off by a little bit, making it very annoying. I have tried getting rid of mouse acceleration, and turning off vsync, and capping the framerate at 60, but none of those worked. Any other things I can try?

Without standard, routine information, are you treating us as if we all are clairvoyant? I'm not, that's sure.

Sorry laptop specs: i7 at 2.8ghz overclocked 6gb of ram, and geforce gt 540m. Anything else you need?

Basic Hardware Specification Chart (Empty so far)

Operating System / Service Pack: WindowsXP with SP #?, Win7, Vista ?
Video Card Driver Version: Catalyst ?.? / Nforce ??.??
. . (please use the numbers, and dates, *not* the word "latest")
Video display's default screen resolution
Video Card onboard RAM: ? ? ? MBs
Sound Card Manufacturer:
Sound Card Driver IDs:
Sound Card Model:

Mouse make and model, and driver data also!

(And this is only for the raw hardware & driver variations. Potential software conflicts are far more likely to be game play problems, and developers cannot test for all possible program loads.)

Windows 7 64bit
Driver: 295.73 Feb 21, 2011
Default Resolution: 1366x768
Video Card Ram: 1024mb
Sound Card Manufacturer: Realtek
Sound Card Driver IDs:6.01.6294
Sound Card Model:Realtek High Definition Audio (Doesn't say anything else in system info)
Mouse: Logitech M305
Mouse Drivers:6.1.7600.16385

Since you tried about everything i would mention...i dont however see mention off

Turn off in game settings....

X-360 controller
Vibration

Not needed unless your also using a controller, but you said mouse, so disable the above.

Just looked up mouse...thats a wireless mouse??...need batteries??

Tried already, nothing.