I tried every thing to play again.
I played for over 200 hours and after the last update nothing works.

Advice please and now from the real specialists.

Please let us play again.

Douwe

Describing the problem a bit more thoroughly than "It doesn't work" might be useful to diagnose your problem so that we can help you. Is it a crash at startup? If so disable all eventual mods, including stuff like Script Dragon. If you have no mods try verifying game cache through Steam.

DX Diag and system specs to start would be great....as well as a full list of mods(if any) and the application you are using to boot the game(if any) and or handle your mods.

Surprise! Bethesda sometimes makes more issues than there were before. A dxdiag would be the best route since it provides the most information about your system. Go to the Run program and type in dxdiag.

Oke m8ts, I found the problem.
This what I did, removed the driver Catalist 12.3 and profile 12.3 CAP 1.
Reinstalled the driver and profile 12.1 CAP 3.
Validated in Steam.
Games is STARTING yes.

In NMM Plugins was before I started empty, exept Skyrim and Update. esm.
Mods NOT installed.

Activated the mods in series of 3.

I will make the story short, after all the mod: Illia Compagnion - Red Head Mage Was for me the problem and I think the Profile 12.3 CAP 1.

So SORRY for my hars words to Skyrim.

Glad you figured it out
I reverted back to 12.1 since it seems to be a tiny bit better for my overall game library.....here is hoping 12.4 is a much better release.