I have the same problem!
Have played this game for many hours in the past but today it fails to load.
The title screen loads OK and regardless of what settings I chose in the Options menu, when I click play I get a Windows message saying 'Skyrim has stopped working correctly.'
The application error log shows an Application Error: 'Faulting application name: TESV.exe, version: 1.5.26.0 ......'
I'm running Windows 7 x64 with an AMD ATI Radeon HD 5800 Series Card. Was running CCC 12.3 and rolled back to 12.1 but it made no difference.
I have verified the integrity of the Skyrim game files through Steam.
Can anyone offer any advice other than the standard 'Try a re-install.' ?
TIA