Even the smallest amount of searching for your symptoms on this forum would find you a massive amount of info on your fixing this.

For me, I use D3DOverrider's Triple Buffering, MSI Afterburner to frame limit (60 fps limit works for me - others have better results limiting to 58 or 59 fps) and I leave the game's v-sync on.
Some find the simple borderless window mod helps too (http://skyrim.nexusmods.com/downloads/file.php?id=4), but it didn't for me.
xTx