If I want to up my uGridsToLoad to 7 (with uExterior Cell Buffer=64) do I need to change anything else along with it? I've saw some people say to also change the allocated memory as well. Should that be done too?

Also, would I need to change my uInterior Cell Buffer too, or leave it as it is?

It is not necessary to change anything else besides uGridsToLoad and uExterior Cell Buffer; as long as you have the hardware to support it, of course.