Did you try to verify the cache of your game in its properties in Steam?
Many times. It never fixed the issue. All mods are deactivated in the launcher, and still the problem persists.
I just re-installed windows 7 yesterday, ALL my drivers, the game, and still I can't get it working. I didn't even have a good reason to delete the game that was working fine in the first place other than a bit of OCDness and now I am totally stuck... what else could it be?
I'm suspicious of the ini. files as I made very careful small changes in there per modder instructors for a couple mesh mods like Floral project, SMIM, etc... But those should have been re-written with this latest re-install?