I'm playing a build like that right now. I'm level 25 so I'm not too far in yet, mostly all I've done is advance the story past Dragon Rising and just completed the DB questline.
Sneak, obviously.
Lockpicking will advance itself, I haven't bothered putting any perks into it.
Archery is a big help for sneak attacking from a distance.
One-Handed for quicker combat and use of daggers.
Illusion for muffle, calm, fury... it's all quite useful.
And of course I'm putting time and points into Smithing and Enchanting to maximize my armor and damage down the road.
It's a very fun class. Nothing's quite as satisfying as taking people down without them ever knowing you were nearby. And the DB questline is just awesome with pretty good rewards both gold and equipment-wise.