Umm, I have not completed that questline yet. But may be check your statistics and bounty (press escape, go to statistics tab, and crime statistics). If you have a specific bounty it should say which hold it is associated with. If the bounty is very high, I think the NPCs start attacking you on sight.
Also, have you changed into werewolf/last stage vampire while in sight of friendly NPCs at some point?
I checked my bounty, it was a little high, but it didn't have mentioned the places i did crimes in, but i'm sure that i didn't do any crimes here.
also im a vampire, but im not sure that i have changed in NPCs sight - actually i dont know how to change. i arrived there at night, is that the reason?