What have you been wanting to do or finish that you haven't yet since you got this game?
I haven't finished any of the guilds except the College. I have never visited Dawnstar. I haven't finished the main quest. I haven't finished the civil war. I haven't gotten the Black Star. I haven't met Cicero. I haven't become a vampire.
Definitely don't become a vampire unless you want to raise the difficulty of the game higher then normal. It's such a [censored]ing hassle to worry about feeding and daylight and it just isn't worth it at all. Lycanthropy on the other hand isn't bad, no negatives besides the sleeping bonus (who really uses that anyway?) and immune to all diseases.
Got my platinum today , took 500 hours 7 minutes across 2 characters . The only thing I haven't finished is the dragon priest mask " quests" , and a few side quests . All the major stuff is done though .