Please do not post spoilers in the general forum, that is extremely inconsiderate.
There are no disadvantages to it
Normally if you sleep in a bed you get an increase to skill progression for several hours afterward, werewolves don't get this.
You can cure this (you are shown how to do this during the Companions questline), although once cured you can't become a werewolf again, and you can't do the quests associated with it (at least not Aela's, I'm not sure about Farkas and Viklas).