What are shrouded gloves? Sorry I'm a total stealther noob in skyrim.
A very nice pair of gloves you get when you join the Dark Brotherhood. Absolute must for a melee assassin

You definitely want Dual Savagery and possibly Fighting Stance and Savage Strike, all in effort to maximize your survival chances - best to one-shot them than just hurt and then get involved in a fight, no?
You need Sneak for Assassin's Blade perk. 15x dagger damage + double that from Shrouded Gloves = win. From the left branch, Silent Roll might be useful; it's a sort of sneaking sprint, it's fast enough for you to get behind your enemy before they ever have a chance to see you. It's up to you if it's worth three perks to get it.
Don't take Stealth any higher than the first tier. High Sneak is enough to make you invisible, especially when you're wearing Muffled boots and specialize in Illusion.
Don't touch Lockpicking! It's an entirely useless tree. Once you get the hang of the minigame, you won't need any perks, only a lot of lockpicks, and they're in abundance in Skyrim. If you really svck at the minigame, though, you might wanna go for the Master perk.
If you plan on using Archery as well, all you really need is Overdraw. Power Shot is nice - it staggers your enemies. Personally, I like Steady Hand, but you probably don't need it. Better to put the perks into a crafting skill

Wear Light Armor, of course, and perk Wind Walker.