Sure. in Skyrim you can destroy the DB but you can also destroy the Companions. since after you become Harbinger the Companions are all followers so they can all die. if you ever wanted to destroy the Companions now you can.

Er. Spoilers and whatnot....

well... it's less "destroying" and more "making room for new recruits".

It's not offically destroying, it's just killing most of the members, the game would still recognize them as still existing