One mistake I made was not choosing one of the 3 Guardian Stones at the very start to level up better. So I decided I was going to create a new character. Because I played more two handed than one handed, I chose the Orc race.
I get through all the initial stuff, get down to Riverwood, and went to craft the iron dagger (that puny side quest) and my game locked up.
When I restarted my PS3 and my Skyrim game, much to my horror, my Level 50 save game was GONE. I don't know if the game autosaved over it (before it locked up) or if I accidentally saved over it (I thought I was sure I hadn't).
Either way, lesson learned: I'll have no less than 5 save games from now on. I hadn't had something this horrible happened since I lost 24+ hours on FFIV back in the day LOL

