Seriously, I'm on my 5th character now. So far, I've only completer the MQ with one character, I used the others to mainly roleplay and use totally different playstyles (one is part of various councils, while the other is a bandit not allowed in cities, for example). But I don't think I'll ever touch the MQ again. In Fallout New Vegas, I've played trough the MQ with every character, even if I roleplayed.
But Skyrim's MQ is quite basic, you're walking a straight line to defeat Alduin. No spins, no twists, no betrayals, no surprises. I mean, there were a few cool moments where you flew a dragon or stepped into Sovngarde for the first time, but that's it.
So.. is there any reason why I should play it again?