You ever notice that when you assign something to your left hand you need to right click and vice versa and when you attack with your right hand you need to left click and vice versa? Well this is a pretty obvious bug, how has Bethesda not yet picked up on this/fixed this?

It's not a bug, it's by design. Kind of like inverted Up/Down controls for flight sims I guess. While it's fine for me I think there should have been an option to change the settings included with the release.

as the right arm is more often used for one-handed fighting by most people, it is assigned to the primary (left) mouse button. i think it is by design