The main quest would be a massive attack by the sloads and their attempted resurrection of the master necromancer N'Gasta.
edit] N'Gasta (?b- http://uesp.net/wiki/Lore:Second_Era#2E_864)
http://uesp.net/wiki/File:RG-npc-N%27Gasta.png
http://uesp.net/wiki/File:RG-npc-N%27Gasta.pngN'Gasta in http://uesp.net/wiki/Redguard:Redguard "No trust dark Worm N'Gasta. Powerful, yes, is N'Gasta -- But wicked. Soulstealer. Old and evil." — Joto, mage in http://uesp.net/wiki/Redguard:Redguard Someone thinks the http://uesp.net/wiki/Morrowind:Masque_of_Clavicus_Vile is here on http://uesp.net/wiki/Lore:Vvardenfell. Apparently there are many copies of 'http://uesp.net/wiki/Lore:N%27Gasta%21_Kvata%21_Kvakis%21' here on Vvardenfell. N'Gasta was a great http://uesp.net/wiki/Lore:Sload http://uesp.net/wiki/Lore:Necromancy and servant of http://uesp.net/wiki/Lore:Clavicus_Vile in the http://uesp.net/wiki/Lore:Second_Era, and he may have had a wizard's tower here. An agent came to me asking questions about N'Gasta. The agent would not give his name, but I have learned he was in the employ of someone named http://uesp.net/wiki/Morrowind:Sorkvild_the_Raven_%28person%29." — http://uesp.net/wiki/Morrowind:Artisa_Arelas, Dunmer Pilgrim
The book http://uesp.net/wiki/Lore:Bible_of_the_Deep_Ones contains parts of http://uesp.net/wiki/Lore:N%27Gasta%21_Kvata%21_Kvakis%21. The necromancer was killed in http://uesp.net/wiki/Lore:Second_Era#2E_864 on the Isle of N'Gasta by http://uesp.net/wiki/Lore:Cyrus the http://uesp.net/wiki/Lore:Redguard, who wielded the Flask of Lillandril.
More lore would have to be written but basically the sloads would be attemting to bring him back as a sort of lich and simultaneously launch assaults on the cities. That is undead would walk the streets at night.
So you start the game once again as a prisoner (i don't think we're gonna break beth of that habit). You are being brought to your cell. The whole building radiates decay. To your left guards cart out half a dozen or so dead bodies. As you watch one of them is grabbed by a hand that jumps out of the pile. There is a scream and then silence. The rest of the bodies rise off the cart.
