I've never had the stones to actually try this, mostly because I feel like if I'm really being hardcoe about it I would start over no matter what the circumstances were. And I wouldn't have the heart to start from scratch every time some bug contributed to my death, or I looked away to take a drink and accidentally fell down a cliff that really shouldn't have killed me but Skyrim has ridike fall damage.
the first rule for many in DiD is that if you die due to a bug it doesn't count. reload with impunity.
for me, if i die for a silly reason like taking a drink or some controller issue, i reload. the controller, especially, since it is a very imperfect piece of equipment and forgetting it's layout or pressing the wrong button happens all the time. reload.
accidentally falling off a cliff, though, and it's time to re-roll the character sheet, lol.
the thing i really like about DiD, aside from the intensity, is all the different character types and subtypes i can play around with. these DiD's are where i do my VERY STRICT rping, as well.