So I work my way through the Twilight Specter quest, and I got to the end, giving up my Skeleton Key.  You're supposed to talk to the girl, and all 3 exits are purple; you can't get out.  I keep trying to talk to her and nothing happens.  And there's no way out of the room, so essentially I'm done for.  It's a good thing I had another save backup or I would have been SCREWED.