Yes, I do notice it in some rather specific moments.
Here is a list
1: Particle effects emitted emitted from waterfalls.
2: Particle effects emitted from a dragon priest directly after death.
3: Certain areas in caves where there is a very bright light, usually coming from an opening in the cave. I believe this is apparent in a few areas of Bleak Falls Barrow.
4: Makarth has an overall sluggish feel to it. It seems to only be an issue when you are facing the majority of the city at one time. It doesn't seem to take as much of an effect when you stand in the middle. It was
really bad if you *POSSIBLE SPOILER*
Spoiler chose to escape with the Forsworn from Markarth's jail in the The Forsworn Conspiracy quest. The battle taking place after leaving the jail seemed to bring the Xbox to its knees....as if somebody had taken an arrow to one of the- *gets shot*
5: In Riften, there seems to be a slight amount when viewing the center area where the stalls are set up from a distance. When there are fewer NPCs in the area (nighttime), it seems to go away. Riften also seems to chug a bit as if it's loading something every couple minutes.
6: In the Thieves Guild's headquarters, The Ragged Flagon, there is a very slight frame rate drop when viewing the entire main room (the area where the majority of the thieves are with the big circle of water). I also remember a drop in the area outside the room where *POSSIBLE SPOILER *
7: The Dark Brotherhood Dawnstar Sanctuary, *POSSIBLE SPOILER *
Spoiler Particularly before it's rebuilt.
8: Particle effects emitted from the geysers in the Eastmarch area.
I'll add to this list if I find/remember more.