Is it possible to have a global variable that stores an ObjectReference? Or if not have one script listen for two objects events, such as ObjectRef1.OnActivate(Blah), ObjectRef2.OnActivate(Blah)?

I haven't tried this yet, thou this works in OBSE
You can create a new quest. This quest doesnt need to be running. Inside that quest, you create some variables you want to store, but make sure to set them as Property, so other script can access that.
This quest now acts as a database (well, hopefully)

Try it, and let us know if it works out

Thanks I will give it a go.

Not sure about how it worked in oblivion but doesn't seem to meet my needs..