I don't think it is, although you can add multiple effects to an enchantment and have different ones active depending on certain conditions.
You could, I think, attach a http://www.creationkit.com/Papyrus_Introduction#Writing_Custom_Functions script to your object, and have its enchantment change depending on the state of a property declared in that script. Properties can be accessed externally, so if need be you could have another script modify the state of each weapon independently in order to modify its enchantment.
Cipscis