That the game disk I might get is not effected by the enemy respawn bug that causes enemies to not respawn in the.wilderness, and yes I am running a new character I made for 1.6.

Is it also possible I will not have the plant respawn bug?

Bugs are present in the Skyrim data files, either in the ESM, EXE, BSAs or other loose files. Your disk will have nothing to do with it, and each disk will contain the exact same files on it. You'd just be wasting your money.