Thumbs up for the Chicken ans Egg method from me again for FNV and prior games.
The biggest problem with that was not all modders adopted it.
I'm not sure if the same kind of method would work with Papyrus, or if it did work, it would just leave heaps of error messages in the error log when SKSE is not found.
I'm hoping we get it at SKSE level this time.
I made a http://www.gamesas.com/topic/1356343-wipz-skyrim-script-extender-skse/page__view__findpost__p__20484748 in the SKSE thread a while back, not sure if it got glossed over though.
Maybe by mutating (a useless for modding) command such as Debug.GetPlatformName() to perform the check in our mod and avoid the extra SKSE features if it still returns 'PC'.