This is what I am trying to do. I want to give the player the option of bribing an NPC with 500 gold. If the player clicks on the option to give the 500 gold to the npc, I want the result to be based on the current players speechcraft skill.

Example:
I meet an NPC. He has information I want him to tell me. I offer him 500 gold. The game checks if I have a speechcraft skill of 25 or greater. If I do, I get response #1, if I do not, I get response #2.

Any help with explaining how to do this would be great. Thanks!

You want two responses in your topic each has it's own conditions

GetAV Speechcraft >= 25 and is run on the target (Player)

GetAV Speechcraft < 25 and is run on the target (Player)

You should review http://www.creationkit.com/Bethesda_Tutorial_Dialogue