The best magic races are probably Altmer (High Elf) and Breton. Altmer get a Magicka bonus and overall more racial bonuses to magic schools, but Bretons get a constant resistance to magic, which is arguably more valuable. Do you plan on using armor? If not, you should pick up Alteration for the Flesh spells (as well as the Atronach alteration perk, and the Paralyze spell). As for your sign, I suggest The Lord (again assuming you're going unarmored). Another option would be to go with armor and pick up The Steed sign. Honestly I would drop Destruction if I were you: it's pretty underpowered at high levels, and Conjuration should be sufficient for your offensive needs -- especially when combined with Calm and Frenzy from Illusion. Oh, and pretty much regardless of your decisions in the aforementioned skills, you'll probably find yourself using Restoration as well. So basically, the way I see it, you have a few decisions to make:
1.) Race: Altmer (offensive-minded) or Breton (defensive-minded)
2.) Defense: Heavy Armor (with Steed sign) or Alteration (with Lord sign)
3.) Primary offense: Conjuration or Destruction
Depending on the choices you make here, you might want to consider adding Sneak. If you plan on focusing on summoning via Conjuration, supplemented by Illusion and Alteration, Sneak isn't really useful. But if you use a lot of bound weapons and/or runes, and you're using Steed + Heavy Armor, Sneak can be a big help.