ASIS can run alongside Deadly Combat? What about SkyTest?
Haven't tried SkyTest, but Real Wildlife is kind of similar and it works fine. For ASIS, you have to add the PISE Deadly Combat patch at the end of your load order, after ASIS.esp
So far I'm just using the vanilla Skyrim launcher, haven't needed to install Wrye Bash, BOSS or NMM yet.
I will have to check out ASIS - looks good. I must admit the 2X Master mod is a bit of a hamfisted method.
The amazing part of ASIS is when you have a lot of spell mods installed, and it assigns some of these powerful spells from your other mods to NPCs to use against you. Also they use healing potions, etc.