Dragons, Especially at higher lvls. I frequently find myself trying to get to my objective only to feel a sharp gust of wind and me thinking "please, just circle around and leave me alone...."
And if it's flying too high to detect me it usually flies off.... and attacks a distant town... Full of quest related NPCs

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Forcing me to take a detour from my current nearby objective, run half a mile to the town, Kill the dragon, only to re-load the save because someone stupid enough to go after it with an Iron dagger got killed!
