No they won't, I'd you're silent and invisible with a decent sneak skill, nothing will detect you unless you bump into them.
Yes... they will. Read my post carefully. I am talking about muffle and invisible --without-- sneaking. Humans will "detect" you, but cant get a lock on you and attack effectively, but animals will detect you with both muffle and invis unless you sneak.
That is why i said he needs to be in sneak mode as he is specifically mentioning an animal detection.