FWIW I'm using an MX518 just fine with this game. I have no idea why it would cause issues for you.
What is meant, I believe, is that you can't map actions to the mouse buttons. For instance, I use Left mouse for Forward and Right mouse for Back in all of my FPSs. This game does not allow that mapping - at least from the options ui.
edit: Nevermind, I read the readme, which the OP should as well.