I was playing around in the GECK and decided to see if I could make 1000 rads non-lethal. After playing around with certain effects, I decided to make a releasable mod out of it.

This mod alters the Radiation1000 disease, renaming it from "Lethal Radiation Poisoning" to "Crippling Radiation Poisoning". The effects are changed from -10000 health (instant kill) to

• Permanently crippled limbs (while Crippling Radiation Poisoning is in effect; they can be restored but will be immediately crippled again unless your rads are reduced below 1000)
  
• Health: +10/sec with the Rad Child perk, or -1/sec without the Rad Child perk
  
• Reduced carry weight of 1000 points, making it impossible to run no matter how much loot you drop
  
• Strength, Perception, Endurance, Intelligence, and Agility reduced 3 points, in addition to the -2 Perception from a crippled head

In addition, rads will keep accruing as long as you're in an irradiated area or take other actions that would normally increase your rad count, making it more and more difficult to reduce your rads below 1000 on your own. A doctor *should* still be able to remove your rads in one treatment, but I haven't tested that yet, you might need one per 1000 rads, plus one more for whatever's left over. Either way is fine with me so I didn't worry about testing it.

http://www.newvegasnexus.com/downloads/file.php?id=37361