Ok!
Played this about 12 hours now and here are some bugs I have found:

If you put lasersight to classic pack weathered 10mm pistol you get missing mesh (no gun and you only see your hands) and pale green screen instead of lasersight. also weapon sound is missing after that too.
Need to test how that weathered pistol does with silencer mod when I find one.

The side quest in novac with killed brahmin also seems to be bugged badly. The "killer" comes to next to brahmin pen but then does nothing. He doesnt shoot the brshamin, just stands there 24/7.
(tested this by waiting. he standed there for few days then I got bored and reloaded the savegame)
Killing him doesnt make any difference as what ever I try to do i get "not yet" as response from converstation from the fella I got the quest. Even I loot everything from the corpse. Some other forums says that player needs to loot holotape after killing him, well theres no holotape, only a note. And looting it doesnt do any good, can't finnish the mission.
Spent 3 hours real time to try do this mission in every permutations I could possibly figure.

Also there seem to be really bad lag with controls. I can't enter vats sometimes, no matter how I hammer the vats key nothing happens. Also sometimes weapons just wont shoot. Some time when I shoot without ironsights, weapon shoots like 90 degree angle to random direction. I know that if I would have low guns skill there would be some spead on shots but 90 degree with guns 75 is a bug!
Not sure if this is already addressed but key "2" doesnt work either. I got hollowpoints, armor piercing and normal rounds in my inventory for my rifle but button "2" does nothing. I have to change ammo from the inventory manually.

Not sure how repair skills should affect your repair but I can repair everything to 100% condition with repair skill of 17?

Also sneaking seems to be somehow broken. I got high sneak skill, have been putting all my skillpoints to guns and sneak. However when I was doing mission involving some ghouls and rockets
I tried to sneak inside the building, ghouls seem to spot me from far distance even they didnt have line of sight and I was NOT wearing any armor, only sherifs duster. Kinda stupid to try to sneak when every enemy inside a building knows where you are in the moment you enter the building.

Had only one CTD and my saves seem to work fine.

But anyway the game itself is super! Feels very much fallout. I just love the hardcoemode!
I hope devs get the bugs fixed and mod community makes more unoffical fixes!

cheers!