After learning Power Armour skills via the Brotherhood quest line every auto save is corrupt, so If I zone some place I get a black screen, when I reload the xbox the save is always corrupt.
Without finishing the Brotherhood line and no Power Armour, If I zone into the Strip via train or North Entrance I get a blank screen & when I reload the xbox I get corrupt save. I have tested over the last day with several save files at different stages and all = black screen auto save corrupt.

If you take ED-E to black mountain he will get lost 100% of the time for me. I took many paths and he will stop just after the first gate/baracade. If you send him home here or all the way at the bottom of the road he will be lost forever. Never showing up in Primm.
-after he gets stuck if you tell him to wait or you tell him to follow he stay & once out of sight will not be there when you get Line of Sight to his last location, never to return.

I tested all this over the last day with many save files, and all ended the same.

ED-E bug - Ok I can lose a companion
Vegas Strip Bug - I cannot finish the game.

I am sure there are many of these but I haven't seen exactly what I am experiencing, anyone with ideas about the autosave bug please fill me in, as obviously I am a bit screwed right now.

With auto saves off I get the same Blackscreen. I have let it sit black with no sound or noise for over 10 minutes before with no sign of stopping and fearing damage I haven't let it go over 10 minutes.

Damn that svcks man I hope they fix all of this non sense soon

UPDATE - Literally killed my 360. Stopped reading disc's all of a sudden. I was excited. I thought oh my issue was just a bad xbox...... Bought new slim 360, & swapped game hoping that the disc or hardware was the issue..... No such luck. I spent the day loading saves, & getting the same dreaded blackscreen when trying to get to any of the endings.

I was at 90 hours of game play, reset back on every save to hour 57 and am able to zone into vegas without the crash. What happened in hour 57. I killed Ceasar. I then went and chose to help Mr house, i gave chip watch his robo demo & sure enough when trying to zone out of the lucky 38.... blackscreen. So I sterilize House, and try to zne out of lucky 38, blackscreen.

I say ok screw it & restart with a new game on a new harddrive from the new system. I throw everything into int & cha & get science & speech up only. I run down the road to new vegas, pass a robo speech check & zone into vegas. I go straight to house, then pay benny a visit, and whack him in the room. When I return to lucky 38 when i try to zone back out no matter my choice inside.... BLACKSCREEN..........

I LOVE THE GAME!!! Please let me finish it!!!!!

Other bugs
Van de grafff's - after completeing guard duty, when guard goes inside I picked the locker & grab the van de graff armour I was just wearing... Once picked upm, it cannot ever be traded, dropped, and the weight does count. - this + hardcoe mode = grrrr

Vegas Strip North entrance - Requires Key non-exsistant key- Took all gear off to verify not a faction issue, I have a pass, & passed an early robo speech check. Can however take the train in the other side still, but will always blackscreen entering into North Vegas Strip Once inside the 38 or gamorah.

Speech Check loops - There are countless speech check loops, where you can redo speech checks in conversation infinate times. An example of this is found in the Camp Mcarren after getting the quest to get the research data from vault 22 if you talk to the doctors assistant, you can ask about the doctor, pass a 25 speech check for 33xp, ask what she does then ask about the doctor again, and pass the same 25 speech check for the same 33xp, wash rince repeat it is infinite.

I took launch week off to play through this game. The story is marvelous. I love the game, have spent over 100 hours in game & would love it a lot more if I could see one of the endings, please.

I started getting this one tonight after installing the fall update. Thought maybe it was related. Anytime I try to access the Vegas Strip, it loads and then goes to black screen. Looks like I was wrong though just another unfixed bug.

I played roughly 40 hours without a hitch - I download that XBOX update this evening, and boom - freezing left and right, and now I have the EXACT same issue with the Vegas Strip and the black screen. Keeps corrupting files. *sigh*

Ok... well... I just read the FAQ and did what they recommended and I loaded my last save that would actually load - and I went and purchased the Old Cowboy Hat from Mick & Ralph, and voila - I was able actually enter the strip!!! WTF? This better get fixed with the next patch, but at least I can continue to play now...

hahaha ive played way too many hours ive frozen at mick and ralphs the black mountains the hoover dam right before the legate camp..etc. i really dont mean any disrespect but i feel like bethesda pushed the game out to make its money before call of duty but ya ...prolly gunna be a couple updates before too long