I keep my controls at default, and after an unfortunate encounter with a blind deathclaw (very anti-exploration), when my game loaded from the last save, I noticed that closing the pip-boy caused my guy to shoot. I tried using R1, nothing happened. I paused, set the controls back to defaults, and when I unpaused, my guy fired again. It turns out, both usual ways of attacking (R1 and using VATS) didn't work, when I tried VATS, it slowed down, and took the usual amount of time as it should've for the shots I tried, but my guy never shot, and AP wasn't used. Closing the pip-boy, unpausing, jumping (or well landing after a jump) and closing VATS (by using circle to back out) were oddly, my only ways to attack. Now, I tried loading again, and same problem happened. I then decided to take a break and loaded from a save further back, and that fixed it I guess... Using the 2nd generation 80GB PS3, oh and if it's worth mentioning, I downloaded my classic pack somewhat further into the game then usual (was resting in Goodsprings, but on my way to Novac).
Pretty major bug imo.