Just did some more testing... before talking to Bright my save worked but afterwards, all saves are corrupted, even when I don't talk to Bright and just leave. I went to a save before killing Davison and was able to leave and save normally. Davison is bugged and attacks you when he shouldn't so maybe that is related somehow.
Anyway, avoid this quest and save often.
I have the same problem. After searching all over the internet, I found a lot of reports that the quest "Come Fly With Me" is the cause of the save game corruption. Some speculate it's the space suit, some think it's the quest itself.
Thankfully, I've been doing manual saves (not quick or auto) constantly. The last save game of mine that works was during the "Come Fly With Me" mission so I did some testing - I saved my game after every point in the quest and immediately tried to reload it. Every save worked fine until I spoke with Bright after clearing out all the nightkin. Once I spoke with him and all the ghoul NPCs start running down the stairs, every save afterwards is corrupt. I did not get the space suit so that does not seem to be the cause. This happened to me after the 2 patches which confirms the patches do not resolve the issue.
My advice is to avoid this quest until a new patch that specifically says it fixes this issue is released.