For those with the new patch who are half-way through a game:
I highly suggest starting a game from scratch after downloading the patch. Any quest bugs, like bad triggers, could still possibly be there since you've already been playing. it's kind of complicated...
imagine this: your exploring a vault, and come across a computer. it has a "very hard" lock, so you wander around looking for a password, hoping there is one. you find it, and your sure it's the proper password cuz the wiki says so, yet it won't unlock the computer. this is a scripting/trigger bug.
Because the faulty trigger/script has already played out, it's a possibility that no patch could fix it, because you've
already activated the trigger. I noticed this problem many times in both F3 & NV. If you notice quest bugs are still there, you may want to try loading a previous save from before you attempted the quest, or just start a new game entirely.
Edit: And before you take this lightly, Gstaff suggests it as well if your still experiencing problems.
If you're running into issues still, try rolling back to a previous save before issues started setting in.
Taken from here: http://www.gamesas.com/index.php?/topic/1123617-game-updates/page__pid__17538451#entry17538451
I would have quoted the post directly but it's from a locked thread.