The good thing is you can go with an intel chipset, but grab an ATI Radeon card, or go with an AMD processor with an Nvidia card. Each has their own pros and cons when you start looking deeper and deeper into things. It's all about how far you want to go down the rabbit hole to learn about things. When you start talking about varying technologies such as nanometer vs nanometer, things can get very confusing.
Intel is pretty stable for processors, however, they can be pretty expensive. Nvidia is good for GPUs, but I stick with Radeons. Only reason some go for Nvidia is the extra processor that is dedicated to physics processing. Personally, I equate the processor to an extra cherry on top. Some want it, others feel it just isn't worth it.
Recently replaced my 5870 card because the fan was humming loudly, upgrading to an ATI Radeon 7970. It runs pretty much everything I can throw at it. Far Cry 3 being a prime example where everything is cranked up to high with only a few settings turned to medium. I rarely dropped below 60fps throughout my entire playthrough. Only time I had a major fps drop was towards the end with a lot of particle effects going on. The fps drop happened two or three times, lasting for .5 to 1 second at the most.
Spoiler
The particular scene was the ending with Citra where the main character is in the smoke filled room, bound and tied up.