Same questions to you...
What sort of weapon(s) do you generally use? Strategy when fighting?
With my main character, I'm generally sneaking around a lot, taking potshots from distance, etc. I'm a bit afraid of running in full force, trying to melee enemies, just eating bullets left and right on the way there....
that was my exact strat in FO3, sneaking sniper using vats, but with the changes to vats in new vegas i scrapped that pretty quick and switched to this
i put all my skill points into barter,guns,melee,repair,medicine,science,lockpick
i just use any good guns i can find for range attacks, i turned true iron sites off so i can actually see what i'm shooting at, and melee when something charges me, or when i'm in cramped spaces indoors
i don't use vats at all
so far the characters been a huge success, only thing it's lacking in is speech challenges, but luckily alot of times in dialouge there's an alternative skill or attribute that can win a discussion instead of speech.
just hit level 18, got almost 400 hit points, can carry 350 lbs with strong back perk, most of my choice skills are 75 or close to it, and having no problems at all in combat, havn't tried fighting deathclaws just yet, but havn't had any trouble killing everything else i've come accross
and i can't say enough about having 10 luck, tons of criticals, easy lockpicking and terminal hacking, and slaying the blackjack tables

i highly reccomend giving it a try