Ive been playing with the Ballistic Fist for the past half hour with 30~ Unarmed skill and ive been one shot killing Deathclaws with a frontal Power Attack. I also dont have any of the melee/unarmed enhancing perks like Piercing Strike(?). With 100 Unarmed I think you could literally run around OHKing everything with normal hits. I also earned the 10,000 Unarmed damage Achievement in this 30 minutes.
This thing should use Shotgun ammo or something.
Yes. Fun!
Veronica will show just how deadly that weapon can be...
There are two Special power fists in the game, I got them both, but never used them as much as I probably should.
I got 'Pushy' which is an extra-nasty fist, plus I got a special one that pulse-damaged robots in one shot.
Should have used them both more (but I like my Fire Axe).
Also - chainsaw is awesome if you find one near the end.
Are you on normal difficulty?