I figured it was a mod or bugged save file, so I tried reverting to earlier saves and tried loading with all my mods removed. No dice. Even saves way before the issue cropped up have the bug. Switching to a different weapon or unequipping/reequipping = no weapon equipped. After checking online everywhere for someone who found a solution I haven't even run into anyone who has this issue...
So I tried starting a new game (with no mods installed). I finally got to the point where you have a Pip-Boy again and found that the issue was still there... So it's not a script issue with a save file, but something wrong with my game.
So I tried uninstalling and reinstalling. No dice.
A game that worked ok (with the occasional bug) now is (unless I want to play an unarmed fighter) unplayable. WTF? All I can think of is that it's something caused by the patch... But if so, wouldn't someone else have posted about the same problem? I mean, it's 100% reproducible with new games, all my saves, fresh installs, etc....
I'm in the midst of uninstalling/reinstalling for the 3rd time (this time with auto updates turned off in steam).... Has anyone else seen this problem?