Everytime I try to leave the Lucky 38, it goes to the loading screen, then it goes black and just [censored]in stays there. I have to hard reboot my xbox and the AUTO save says its Corrupt. WTF

i am currently experiencing the exact same problem and it has essentially ruined the game for me. i kept saving over the same file and i am currently 44 hours in and completely stuck in the lucky 38.
i do have a theory for my own problems though, i had two followers one of them was the dog rex. i wanted to have a stronger companion so i told rex to wait in the lucky 38. after doing that it would not allow me to have another companion and was registering that the dog was still in the same crew. when i went to the vegas strip for the next time a problem became clear. going through the front door kept locking up my system so i went the back way through the train. i made it into the lucky 38 to get the dog back and am now stuck.

fallout is my favorite franchise but this just svcks and i am about to just return the game but it svcks ass that i would have to turn it for a used value of 25 bucks after paying 60 a week ago. thank you makers of fallout you really screwed me and like a bunch of other people i will not be buying any more of your products.

My followers were waiting outside, on the strip. (first time in lucky 38 to talk to mr house). So i have no idea what is causing it, but yeah im not reloading 5hrs back to try it again.