Have you tried updating your Nvidia/amd drivers to the latest beta ones?
Have you altered your ini files in any way? Cell buffer, ugridstoload, or memory allocation?
Yes, I have uGrids at 9, it's been that way throughout most of the game, I am aware of the problems this can cause, but this problem seems to be more to do with spawning, I had similar in FO3, had to use the editor to remove the offending spawn before I could get near the red bicycle factory, unfortunately in this case that's not an option.
Edit, ATI card drvers are the latest beta 12.1